We concluded that the normal range of BUN and Cr levels differed between young and elderly subjects, and that the decline in renal function correlated with age after the seventh decade. So, what does it mean if your BUN level is at the very high end of the normal range If I see that it’s borderline high, I might ignore it, says Dr. Value in milligrams dissolved per Liter., Creatinine. Excess urea is removed from the blood by the kidneys, so high levels of BUN in the blood can indicate that kidney function is declining. Although Cr levels did not correlate with age in elderly subjects, Cr levels divided by body surface area significantly correlated with age. Study with Quizlet and memorize flashcards containing terms like BUN Normal Ranges: -Value in milligrams dissolved per Deciliter. Significant positive correlation was found between BUN levels and age in male elderly subjects. The mean Cr level in the elderly subjects was slightly higher than that in the control subjects. The mean BUN level in the elderly subjects was significantly higher than that in the control young subjects. The estimated normal range of BUN was 14-23 mg/dl both in male and female elderly subjects, and that of Cr was 0.9-1.3 mg/dl in male and was 0.7-1.1 mg/dl in female. We defined the normal range as range within the single SD-line of the remainder. ![]() We calculated the mean and the standard deviation (SD) in each group, and excluded subjects with values beyond twice the SD-line. This study was a part of the Kahoku Longitudinal Aging Study (KLAS) that aims to reveal the comprehensive functions in the aged. We measured the variables also in 315 cases of sex-matched young control subjects (male, 139 female, 176). The normal range for healthy adults and adults with CKD is less than 100 mg/dl. The blood in the gut gets digested and this increases the amount of protein and BUN levels 12, 13. Dehydration increases the blood levels of both BUN and creatinine but increases BUN more than creatinine. High levels of LDL are bad and associated with a higher risk of heart disease and stroke. A BUN/Creatinine ratio above the normal range can be caused by: Dehydration. LDL (Low Density Lipoprotein) This is known as the bad cholesterol. This can also help to slow the progression of kidney disease.To estimate normal ranges of blood urea nitrogen (BUN) and serum creatinine (Cr) levels in the aged, we measured BUN and Cr levels in 332 cases of apparent-healthy elderly subjects (male, 152 female, 180) aged 70 years or more. The normal range for HDL for healthy adults and adults with CKD is 40-79 mg/dl. For overall healthy kidney ensure that you keep your cholesterol, sodium, potassium, and protein in check. A normal level is important to avoid kidney related diseases. To maintain a normal BUN: Cr ratio you may have to take medication or to alter your diet. The normal ratio range for the BUN to creatinine is commonly between 10:1 and 20:1. You can also use some treatment like salvia and WH30+ to treat renal failure and reduce creatine levels.Drink ginger- it can help remove urea in the blood.Treatment for an Elevated BUN Creatinine Ratio may Include: Itching and Swelling (in the extremities).Lower Growth Hormone- Usually, growth hormones can inhibit urea synthesisĪ high BUN to creatinine ratio is mostly associated with the following symptoms: Non-fasting blood sugar tests don’t require an individual to abstain from eating beforehand.Thyroid Abnormalities – They cause abnormal kidney function.In case you have a BUN Creatinine ratio 22, you may be just fine as it is barely above the normal range.Īn Increase in the BUN: Cr Levels May be Caused by For instance, is you have a BUN Creatinine ratio 24, it means you could be slightly dehydrating. An increase in this ratio can result due to a decrease in the flow of blood to the kidneys. ![]() Exercises can also increase muscle massĪ high BUN: Cr ratio is the level above 20:1.Avoid drinking alcohol- Alcohol can negatively affect the way your liver functions.Avoid drinking too much water- This can reduce creatine levels General reference ranges for a normal BUN level are as follows: Adults up to 60 years of age: 6-20 mg/dL Adults over 60 years of age: 8-23 mg/dL.Proper diet- consume foods with enough proteins, fruits, and vegetables.You can Elevate a low BUN: Cr Ratio Levels by: Anabolic Steroids- They decrease protein breakdown.Pregnancy – As a result of increased plasma volume.
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HTML colors, CSS colors, SVG, and various other image formats). If the entire colour wheel is specified then it produces numbers from the entire range of each of the hex triplets which are six-digit hexadecimal numbers used in computing applications to represent colors (e.g. The basis of the functionality is a random number generator which produces random numbers in a specified range which depends on the selected color palette. It's virtual "color wheel" consists of 16,777,216 colors, to be precise. However, most modern screens and monitors can reproduce over 16 million colors and so this is also the range of colors our color generator picks between. In theory, we could draw a random color from that infinity. The human eye is pretty good at what it does and can distinguish between about 10 million colors. How many colors does the random color picker choose from?Īs colour is simply visible light at a certain frequency, there are, for practical purposes, an infinite number of colors since the frequency range can be divided almost infinitely. Our random color generator will output the randomly chosen color in all three systems, for your convenience. Roughly speaking, hue refers to the part of the light spectrum (0-360°), saturation to its intensity (0-1, 0-100%), and lightness to its brightness (0-1, 0-100%). HSL stands for "Hue, Saturation, Lightness" which is an alternative way of encoding colors.A color written in RGB consists of three numbers, each signifying the amount of red, green and blue light that needs to be mixed in to produce the desired end color. RGB stands for "Red, Green, Blue" and mostly applies to digital displays, computer monitors, television screens and so on.For example, the HEX code for the color black is #000000 while the HEX code for a color in the purple range is #8f0f8d. HEX is just a group of six hexadecimal digits and is a representation often used in web design.Three of these are supported in our random color picker: These are various systems for presenting colors in a technical and uniquely identifiable way. The maximum supported number of unique colors is twelve, regardless from which palette they are being picked. Ideally, use a palette with as many colors as the number of unique ones that you need, or slightly more. Additionally you can use the 3-color wheel consisting of the three primary colors ( red, yellow, blue), the 6-color wheel which has the three secondary colors ( orange, green, violet) on top of these, or the 12-color wheel which contains the six tertiary ones in addition to the primary and secondary ones. ![]() The color generator supports randomly choosing between red and blue, red and black, and black and white. for players in a game, first input the number of players in the first field, then select an appropriate color palette. ![]() If using the random color wheel to generate distinct unique colors i.e. ![]() For example, to pick two random colors, enter "2". If you want to pick more than one colour simply enter the number required in the first field. The output is the color, visualized, and its unique code in HEX, RGB and HSL. Our software uses a strong random number generator to produce the values of red, green, and blue that comprise each color. Press the "Pick a Random Color" button if you want the random color generator to produce another color for you. To randomly generate a color (or 'colour' in British English) simply load this page. How many colors does the random color picker choose from?. so I don't think I can just go to a Microsoft Store. What can I do? Office 2007 is not exactly sold anymore. Now I have 2 licenses for this laptops, 0 of which allow me to install. I can NOT install any other version for compatibility reasons (interfacing with scripts). Feel free to contact us if you need assistance with Windows. We suggest that you download our latest Office products for better experience. To stop Windows Search Service, follow these steps: Click Start, type services.msc in the Search programs and files text box, and then click services.msc in the search results. Method 2: Stop Windows Search Service, and apply Office 2010 SP2. However, you may encounter some compatibility issues. Method 1: Retry installation of Office 2010 SP2. Read and accept the Microsoft Software License Terms, and then click Continue. Hi Harold, Yes, Office for Home and Student 2007 can be installed to your Windows 10. If the setup wizard doesn’t start automatically, navigate to the CD drive and click SETUP.EXE. Run one of these commands in an elevated PowerShell or Command prompt window. This solution benefits from affecting all Office applications with a single change. ![]() I have a license for each installation of Office 2007 on my laptops. Insert your Office 2007 CD into the drive. Solution 2 - An alternative approach is to prevent re-Registering by renaming the file that is called upon to do it. If you prefer modern software that is supported, you can subscribe to Office 365. I'd prefer not to post my license key to avoid problems. So youre depending on other peoples experiences with Office 2007 on Windows 11, and youll be depending on other people for help when something goes wrong. It says X13-90658 and it has another number starting with 00132- and ending in -899 below the license key. I have the license in hand, with the Microsoft Certificate of Authenticity color sicker and QR code, and unless counterfeiters have grown an interest in 13 years old software, I'm 100% positive it is legit. I thought it may be due to the license still being "bound" to the stolen laptop, so I purchased another license, still shrink wrapped. ![]() However, on this brand new laptop that replaces one that was stolen, after having had problems activating Windows (resolved by activating after a phone call) I'm now having a problem installing Office 2007 Pro!! I have 2 other laptops with the exact same setup Windows 10 Pro/Office 2007 working perfectly fine, along with various old versions of Visual Studio. I have Windows 10 Professional 64bit on a Lenovo laptop on which I need to run Office 2007 Professional - and not anything else, for compatibility purposes. According to Microsoft Q&A at the time, the company confirmed that Office 2007 is compatible with Windows 10, Now, head over to Microsoft Office’s site it, too, says that Office 2007 runs on. ![]() The use of an AI-powered About Us Page Generator is not limited to any specific industry or sector. By generating SEO-friendly content, the AI generator increases the visibility of the website and attracts more organic traffic. These tools are designed to incorporate relevant keywords and phrases that can improve the search engine ranking of the About Us page. With an AI generator, users can create a standardized template that can be easily customized and replicated across various websites, maintaining a cohesive brand image.Īnother benefit is the ability of AI generators to optimize content for search engines. For companies with multiple websites or subsidiaries, it can be challenging to ensure that each About Us page reflects the brand's identity and values consistently. Secondly, an AI-powered About Us Page Generator helps in maintaining consistency across different websites. ![]() This not only speeds up the website development process but also ensures that the About Us page is well-written and coherent. Instead of spending hours brainstorming and drafting content, users can simply input some key information about their company, and the AI generator will do the rest. Firstly, it saves time and effort by automating the process of writing an About Us page. The use of an AI-driven About Us Page Generator offers several benefits. These innovative tools leverage the power of artificial intelligence to create professional and personalized About Us pages with ease. This is where AI-powered "About Us Page Generators" come into play. However, crafting a compelling and engaging About Us page can be a challenging task. One key element of any website is the "About Us" page, which provides visitors with information about the company, its mission, and its values. In today's digital age, having a strong online presence is crucial for businesses and individuals alike. What is About Us Page Generator? Introduction
![]() In addition, the player can rename any item – not just items with durability – by using an anvil.Įxample showing a repair of two diamond pickaxes. Also, if the target item is at full durability and the sacrifice does not have any enchantments, the anvil will also refuse to combine the items, unless if renaming the item to a valid name. If the items are unable to be combined, a red "X" appears over the arrow pointing to the slot of the resulting item. Still, it may be worth making the more expensive upgrade if the enchantments are considered difficult to obtain. In the case of tools and weapons, however, this may be a significantly less economical option combining two diamond shovels would cost two diamonds in total, while up to four diamonds could be required to directly repair one. This is a very good deal in the case of a chestplate, for example a full repair (four materials) would total only half of the item's original cost (eight materials). One material can repair 25% of the target's maximum durability. Alternatively, a player can use materials originally required in the crafting of the item ( iron ingots for iron items with durability, diamonds for diamond items with durability) to repair a single item.With the anvil, however, the target retains its enchantments and may gain new ones from the sacrificed items. ![]() As with the grindstone, a player may repair items by combining two similar items.Anvils have two modes to repair items that have a durability rating: ![]() If you have ever watched volleyball I’m sure there has been a stoppage and point awarded that has left you feeling somewhat confused.Īs you turn to the referee to look for clarification you may just see a variety of hand signals which only adds to the confusion. If you enjoyed these tips and would like to keep it close to you at any time, just save this pin to your Pinterest Volleyball Training Board. Too high or too low. Too high signals will look odd and uncomfortable.If you're exaggerated or demonstrative, you may appear to be overbearing. Too casual or exaggerated. You don't want to appear disinterested in the match.The correct call would be "touch", not "touch" followed by "out". A good example would be a ball touched by a player and landing out of bounds on the same side of the net. This will also confuse people and make you look uncertain of your call. Double signaling. Don't show two different signals for the same fault.Always use the 1-2-3 method for your signal sequence. This is confusing for both players and coaches. Simultaneous volleyball hand signals. Don't blow the whistle and signal at the same time.Always blow the whistle first then look around for assistance. Worry about whether the ball was "in' or "out" later. Don't hold your whistle if you are unsure of the outcome. For example, as soon as you see the ball hit the floor, blow the whistle.Late whistle. Since the whistle is the first step in the signal sequence, make sure the whistle is blown immediately when a fault has been committed or when the ball hits the floor.Show the fault and if necessary, the player at fault hold the fault signal briefly.Ĭommon errors with volleyball hand signals. ![]()
Terminal 1 shouldn't even be bothered with at the current moment, in my opinion. The entire world consumes about 12Gb compressed and fits onto a 3-DVD set. You can think of it as SD or standard detail level. There are two versions available: v1.0.1 is an older world scenery build. I agree, most other objects, except for the GA terminal could be covered with those. FlightGear scenery is available for the entire world. It was designed with a easy to use user interface, so it is great for beginners and people (like me) who don't do serious modeling for a career. If you haven't done much CAD modeling, I would recommend that you take a look at SketchUp. I personally use Google SketchUp for my modeling, then export it to. so it would probably be a while before it would be finished. I'm pretty busy with real life, school, work, etc. Here's hoping!Īctually, modeling ground objects is something I'm fairly decent at. The other buildings are probably covered with the shared objects, and with a good shot with Google maps I can approximate pretty well where everything should be and even have some static aircraft positions in mind. Might be better for framerates though! I'll go look around for some Blender info and see if I can pull that off or not. I could probably cobble something together, but it may not look so good. ![]() Raptor831 wrote in Sat 4:55 am:If you're any good at modeling, I could use a ternimal! Modeling is not something I'm too adept at. Can anyone let me know exactly what steps to take to update an airport like this, from editing the layout until I can use it in-game? Raptor831 Posts: 42 Joined: Fri 9:51 pm Location: Raleigh, NC, USA Callsign: N-R831 Version: 2.12.1 OS: Mac OS X, Win XP Also, I'm a bit confused as to the process after surfing the wiki for a while. dat should I be referencing, or what set of data does FlightGear/TerraSync reference? I didn't want to move ahead with this part until I understood what was going on, and I didn't want to have to do my work all over again because I goofed at the beginning. Ive recently redownloaded FlightGear after a few years of not using it. To be sure, I redownloaded that tile using TerraMaster, and the airport wasn't updated. The user can install or deinstall as needed any tile using git and a git bash terminal. TerraGIT is an alternative scenery for FligthGear Flight simulator that uses git submodules to manage the custom scenery by tiles of 10x10 degrees. FlightGear 2.4.0 has a built-in option to keep its scenery up to date and download new scenery areas on the fly. FG Scenery TerraGIT World scenery repository for Flightgear with tiles as submodules. I followed the instructions at the wiki, downloaded the WorldEditor, set up my folders, and downloaded the current apt.dat per the wiki here: I expected to see KCLT with just the 3 runways, but the 4th one was already added in this. The FlightGear development team is proud to announce the release of version 2.4.0 of its free open source flight simulation program. First up was to add the runway and extra taxiways at KCLT. I noticed that KCLT has a runway missing in my version (2.12) compared to RL, and decided I'd try updating the runway and maybe add some life to all three of these airports with buildings and terminals. Decided to use some airports that are close to places I've lived in, which are mostly KRDU, KAVL, and KCLT. ![]() Per the title of the thread "Where to download FGData 2020.4.Downloaded FlightGear for the first time and love it. I saw this thread and added my query here. ![]() This page does not even have a data set 2020.4.0. There is a pushbutton in the dialogue to download proper data files. Even though the install process for fg and sg also included data files. But data version is not compatible with installed fg version. Dialogue says flightgear version 2020.4.0. FlightGear v2. Now when I start running fgfs (which appears to start fine), I get a dialogue that wrong version of data is installed. Torrents now available for the new world 2.0 scenery It's a big set of downloads so get it started and let it run over the weekend. I assumed the downloaded sg, fg, and data were a matching set as they were all git cloned from fg site. OpenGL 3.3 Core Profile: WS3.0 will require us to eliminate the usage of the fixed-function pipeline. TerraGear becomes obsolete in favor of VPB. ![]() The installation process from the wiki included a download of "data" in the install. Produce high-quality scenery using the best-known practices. My system is opensuse 15.3 linux with Mate desktop. A very lengthy time consuming task with a lot of tinkering but completed. I have finally gotten simgear/flightgear to compile and pass tests. ![]() Clip Studio Paint PRO: US$4.49 (tax included)/month (Annual: US$24.99).Windows/macOS/iPad/iPhone/Galaxy/Android/Chromebook Monthly PlanĪ flexible monthly usage plan for a single preferred device (Windows/macOS/iPad/iPhone/Galaxy). If you go through the Galaxy Store, you can enjoy up to 6 months free. The trial allows you to use the app for up to 3 months free. You can draw comfortably with its versatile brushes and high customizability.Ĭheck out a free trial from the Free Trial page. Clip Studio Paint (Windows/macOS/iPad/iPhone/Android/Chromebook)ĬSP is a multi-functional graphics app suitable for creative works, including illustration, comics, and animation.If you want a more drawing-friendly Adobe experience you might want to look at Adobe Fresco. Photoshop CC is suited for intermediate users, so use it if you know what you want to create and are happy to customize your software. Since many apps do not support CMYK, you can use them together. It also supports CMYK, the go-to format used for printed works. Photoshop is software for photo editing, it is quite good at adjusting colors. However, if you are looking for a highly customizable program, Photoshop CC will work well for you. Customizing the pen and brush tools takes time, and features like pen pressure are turned off by default. You can draw in Photoshop, but its main purpose is not illustration or comics. This versatile software can export multi-page data for online, in print, and for videos. Photoshop CC is prominent in the design and photo processing industry, and many design schools use Photoshop to teach students. ![]() Many people also have created brushes and other materials to make the program more friendly to draw pictures with. There is a large community of amateur to professional artists focusing mainly on design and photography. There are also many booksand websites that introduce Adobe Photoshop, but again, there is little information specializing in illustration and comics. You can also ask questions on the community forum, but topics are mainly related to design and photo processing. You can buy a subscription from the official website, Adobe accepts payments through credit card, PayPal, and wire transfer.įor some issues, you can contact the Adobe support team via their official contact form or a chat feature. Note: To use all the features, you must obtain an Adobe ID and register for the trial version.Ĭreative Cloud Photography Plan: $9.99 USD/month Photoshop CC requires some customization, so it is suitable for intermediate artists.ĭownload the full-feature seven-day trial version from the Free Trial Download page. Abundant in features, it is also helpful for drawing illustrations. ![]() A professional graphics software popular with professional designers, photographers, and editors. If you do not then I suggest you take the "start-sai" from the trial version (and put it in your crack version folder) then uninstall the trial so all you have to do is press "start-sai" and it will be there. If you have the trial version then you should press "start-sai" and the elemap will be there. Add this to the folder where your paint tool sai folder is (mine is called PaintTool SAI English Pack) and then put this in the folder titled "elemap". or you can purchase it here ( gum.co/TSOdf ) for $1. The program I use is Paint Tool SAI (the original trial one not the crack) and here is the trial -> /sai/ĮDIT: You can download the last brush's elemap file for only 100 points. If you want to ask questions regarding other brushes just ask and I might make another one of these. So here are some of the brushes I use for my line art, you are free to use these settings as they are or customize them further to your liking. Include a discussion about its growth or decline, how your product and/or service addresses a need in the market, describe your barriers for entry into the market, competitors that may enter the market down the road, etc.ģ. An analysis of your industry and how it is changing. Explain why they want to buy from you and not your competitor and what value-added services you plan to offer to differentiate yourself in the marketplace (delivery, warranty, customer support, special offers, etc.).Ģ. Describe the product or service from the customer’s point of view, including what they will and will not like about your product and/or service as well as the company itself. ![]() Your products and/or services described in more detail, including price points, distribution strategies, an overview of your major competitors and how your products and/or services stack up to theirs.ġ. You can run various scenarios and tweak the numbers until your business makes sense financially and operationally. Our SizeUp tool can give you a good head start in building your business plan. It’s a lot easier to summarize your plan once you’ve finished it.Ī brief history about your company, its products and services, target customers, location, key strengths, the state of the industry you’re in, who the owners are and what the business structure will be. Basically, this is an extended elevator speech every key piece of information someone would want to know about your business in three minutes or less.Ĭoach’s Tip: Write your Executive Summary last. If you’re looking for a loan, state the amount. Include the goals of the business and your objectives. Put some sell into it, be passionate and enthusiastic, yet professional and concise. Summarize what your business is all about. Here’s an outline of the elements needed in a business plan: Even if you did a Business Model Canvas, you may want to do a final business plan – even a brief one – since it will serve as your playbook going forward. If you’re planning on seeking funding, it is essential. Regardless of your financial situation, a business plan is a good idea. These take a much deeper dive into your business idea and includes things like opening balance sheets, income projections, cash flow analysis, target audience, competition, etc. The more traditional approach is to do a complete business plan. It helps you quickly assess an idea and its market potential and is ideal for those who aren’t planning to seek traditional financing through a bank or financial institution. This covers the same bases as a full-blown business plan but in an abbreviated form. The quickest way to prototype a business, even multiple business ideas, is to do a Business Model Canvas, which is covered in Lesson 3 in our Entrepreneur Academy. There is no right or wrong in this regard. Make them as long or as brief as you need them to be. Business and marketing plans can be very simple or very complex. ![]() The first thing you want to do for your business is to create a solid game plan. ![]() MM rarely show BRAF V600 mutations, thus ruling out treatment with BRAF inhibitors (BRAFi) for the majority of MM patients. Moreover, limited data are available on the existence of MM precursor lesions as well as on their molecular hubs sustaining the progression trajectories. A diverse cell of origin (mucosal vs cutaneous melanocytes) and a lack of UV-exposure are associated with a distinct molecular profile. Local recurrence and distant metastasis are common and associated with a very poor outcome in terms of overall survival rate, and the mechanisms leading to this aggressive clinical behavior are only partially understood.Ĭompared to cutaneous melanoma (CM), MM represent a different entity also in terms of biological features. The majority of the patients undergo surgical resection as a first-line treatment, followed by adjuvant radiotherapy to reduce loco-regional recurrence however, this approach results in a negligible clinical benefit. Due to their hidden sites of origin and the lack of early and specific symptoms, these tumors are often late diagnosed. Mucosal melanoma (MM) is a highly aggressive and rare form of melanoma arising from melanocytes at any mucosal surface. Overall, these novel and unique cellular systems represent relevant experimental tools for a better understanding of the biology of these neoplasms and, as an extension, to MM from other sites. The cell viability impairment induced by LY294002 confirmed a functional role for the PI3K-Akt-mTOR pathway in SN-MM cell lines. Consistently, phosphorylation of NDRG1 and Akt activation was observed in SN-MM, the latter being constitutive and sustained by PTEN loss in SN-MM2 and SN-MM3. Moreover, the proteomic analysis of SN-MM cell lines revealed that RICTOR, a subunit of mTORC2 complex, is the most significantly activated upstream regulator, suggesting a relevant role for the PI3K-Akt-mTOR pathway in these neoplasms. ![]() In vitro, SN-MM cell lines were sensitive to cisplatin, but not to temozolomide. Of relevance, the microscopic analysis of the corresponding xenotransplants allowed the identification of clusters of MITF-/CDH1-/CDH2 + /ZEB1 + /CD271 + cells, supporting the existence of melanoma-initiating cells also in MM, as confirmed in clinical samples. All SN-MM cell lines resulted tumorigenic in vivo and display recurrent structural variants according to aCGH analysis. Compared to the normal counterpart, the proteomic profile of SN-MM is consistent with transformed melanocytes showing a heterogeneous degree of melanocytic differentiation and activation of cancer-related pathways. This study reports the validation and functional characterization of five newly generated SN-MM cell lines. Molecular characterization of SN-MM cell lines was performed by a mass-spectrometry proteomic approach, and their sensitivity to PI3K chemical inhibitor LY294002 was validated by Akt activation, measured by pAkt(Ser473) and pAkt(Thr308) in immunoblots, and MTS assay. Moreover, in vivo tumorigenicity of SN-MM1-5 was tested by subcutaneous injection in NOD/SCID mice. The morphology, ultrastructure and melanocytic identity of SN-MM cell lines were validated by transmission electron microscopy and immunohistochemistry. Methodsįive novel cell lines were obtained from patient-derived biopsies of MM arising in the sino-nasal mucosa and designated as SN-MM1-5. Current treatments offer a limited survival benefit for patients with advanced MM moreover, the lack of pre-clinical cellular systems has significantly limited the understanding of their immunobiology. Mucosal Melanomas (MM) are highly aggressive neoplasms arising from mucosal melanocytes. |
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